LY 344864 hydrochloride

Name: LY 344864 hydrochloride
Brand: Tocris Bioscience
SKU: 2451

Tocris Bioscience, part of Bio-Techne | Catalog # 2451

Citations (4)

COA / SDS

Potent and selective 5-HT1F agonist

Key Product Details

Description:	Potent and selective 5-HT_1F agonist
Chemical Name:	N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	387.88

View Full Technical Details for LY 344864 hydrochloride

Technical Data
Citations

Biological Activity for LY 344864 hydrochloride

LY 344864 hydrochloride is a potent, selective 5-HT_1F receptor agonist (EC₅₀ = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K_i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT_1F, 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_1E, 5-HT_2B, 5-HT_2C, 5-HT_2A and 5-HT₇ receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

Licensing Information

Sold under license from Eli Lilly and Company

Compound Libraries for LY 344864 hydrochloride

LY 344864 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 344864 hydrochloride

M. Wt	387.88
Formula	C₂₁H₂₂N₃OF.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1217756-94-9
PubChem ID	56972176
InChi Key	OKUHLSYESBLBCP-PKLMIRHRSA-N
Smiles	Cl[H].CN(C)[C@@H]1CCC2=C(C1)C1=CC(NC(=O)C3=CC=C(F)C=C3)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 344864 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	19.39	50
	DMSO	38.79	100

Preparing Stock Solutions for LY 344864 hydrochloride

The following data is based on the product molecular weight 387.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.89 mL	25.78 mL
5 mM	0.52 mL	2.58 mL	5.16 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for LY 344864 hydrochloride

References are publications that support the biological activity of the product.

Goadsby and Classey Evidence for serotonin (5-HT)_1B, 5-HT_1D and 5-HT_1F receptor inhibitory effects on trigeminal neurons with craniovascular input. Neuroscience 2003 PMID: 14614913
Lee Characterization of LY344864 as a pharmacological tool to study 5-HT_1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Science
Ramadan 5-HT_1F receptor agonists in acute migraine treatment: a hypothesis. Cephalalgia 2003 PMID: 14510923