LY 404187

Name: LY 404187
Brand: Tocris Bioscience
SKU: 5297

Tocris Bioscience, part of Bio-Techne | Catalog # 5297

Citations (3)

COA / SDS

Selective positive allosteric modulator of AMPA receptors

Key Product Details

Description:	Selective positive allosteric modulator of AMPA receptors
Chemical Name:	N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	342.46

View Full Technical Details for LY 404187

Technical Data
Citations

Biological Activity for LY 404187

LY 404187 is a selective AMPA receptor positive allosteric modulator (IC₅₀ values are 0.15, 0.21, 1.66 and 5.65 μM for GluA2_i, GluA4_i, GluA3_i and GluA1_i respectively). Potentiates glutamate and AMPA-evoked currents in prefrontal cortex (PFC) pyramidal neurons in vitro. Has no effect on NMDA- or kainate-evoked currents; also has no effect on K⁺ or Na⁺ ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo. Induces neurite growth in combination with (S)-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro. Also reduces MPTP-induced toxicity in mice. Brain penetrant.

Compound Libraries for LY 404187

LY 404187 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LY 404187

M. Wt	342.46
Formula	C₁₉H₂₂N₂O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	211311-95-4
PubChem ID	9928016
InChi Key	HOQAVGZLYRYHSO-UHFFFAOYSA-N
Smiles	N#CC1=CC=C(C2=CC=C(C(C)CNS(C(C)C)(=O)=O)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LY 404187

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.25	100
	ethanol	17.12	50

Preparing Stock Solutions for LY 404187

The following data is based on the product molecular weight 342.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.60 mL	29.20 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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References for LY 404187

References are publications that support the biological activity of the product.

Baumbarger Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator. J.Pharmacol.Exp.Ther. 2001 PMID: 11408529
Quirk and Nisenbaum LY404187: a novel positive allosteric modulator of AMPA receptors. CNS Drug Rev. 2002 PMID: 12353058
Voss Molecular mechanisms of neurite growth with AMPA receptor potentiation. Neuropharmacology 2007 PMID: 17101156
O'Neill Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease. Eur.J.Pharmacol. 2004 PMID: 14975705