MB 05032

Name: MB 05032
Brand: Tocris Bioscience
SKU: 6618

Tocris Bioscience, part of Bio-Techne | Catalog # 6618

Citations (3)

COA / SDS

Potent FBPase inhibitor; promotes HSC expansion

Key Product Details

Description:	Potent FBPase inhibitor; promotes HSC expansion
Chemical Name:	P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	302.29

View Full Technical Details for MB 05032

Technical Data
Citations

Biological Activity for MB 05032

MB 05032 is a potent FBPase inhibitor (EC₅₀ values are 1.6, 29 and 61 nM for human liver FBPase, human muscle FBPase and rat liver FBPase). Promotes hematopoietic stem cell and progenitor cell expansion. Increases engraftment in primary NSG mice recipients. Also enhances myeloid and lymphoid chimerism in secondary NSG mouse recipients. Promotes glycolysis, glucose uptake and lactate production in umbilical cord blood CD34⁺ cells.

Compound Libraries for MB 05032

MB 05032 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for MB 05032

M. Wt	302.29
Formula	C₁₁H₁₅N₂O₄PS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	261365-11-1
PubChem ID	11289630
InChi Key	XJMYIJPPDSZOPN-UHFFFAOYSA-N
Smiles	CC(CC1=C(C2=CC=C(P(O)(O)=O)O2)N=C(S1)N)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MB 05032

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.23	100

Preparing Stock Solutions for MB 05032

The following data is based on the product molecular weight 302.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.31 mL	16.54 mL	33.08 mL
5 mM	0.66 mL	3.31 mL	6.62 mL
10 mM	0.33 mL	1.65 mL	3.31 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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Reconstitution Calculator

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References for MB 05032

References are publications that support the biological activity of the product.

van Poelje Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb.Exp.Pharmacol. 2011 PMID: 21484576
Guo Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat.Med. 2018 PMID: 29377004