MC 1568

Name: MC 1568
Brand: Tocris Bioscience
SKU: 4077

Tocris Bioscience, part of Bio-Techne | Catalog # 4077

Citations (8)

COA / SDS

Selective HDAC class IIa inhibitor

Key Product Details

Description:	Selective HDAC class IIa inhibitor
Chemical Name:	3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide
Purity:	≥96% (HPLC)
Molecular Weight:	314.31

View Full Technical Details for MC 1568

Technical Data
Citations

Biological Activity for MC 1568

MC 1568 is a selective inhibitor of class IIa histone deacetylases (HDACs). Exhibits tissue-selective inhibition between members of class II deacetylases in vivo; inhibits HDAC4 and HDAC5 in skeletal muscle and the heart without affecting HDAC3 activity. Arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Displays no inhibition of class I HDAC activity or expression.

Technical Data for MC 1568

M. Wt	314.31
Formula	C₁₇H₁₅FN₂O₃
Storage	Store at +4°C
Purity	≥96% (HPLC)
CAS Number	852475-26-4
PubChem ID	11381449
InChi Key	QRDAPCMJAOQZSU-KQQUZDAGSA-N
Smiles	CN1C=C(/C=C/C(C2=CC(F)=CC=C2)=O)C=C1/C=C/C(NO)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MC 1568

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.43	100

Preparing Stock Solutions for MC 1568

The following data is based on the product molecular weight 314.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.91 mL	31.82 mL
5 mM	0.64 mL	3.18 mL	6.36 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for MC 1568

References are publications that support the biological activity of the product.

Mai Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia. Mol.Pharmacol. 2007 PMID: 17666592
Nebbioso Selective class II HDAC inhibitors may impaor myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. EMBO J.
Mai Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamines. J.Med.Chem. 2005 PMID: 15857140