Milrinone

Name: Milrinone
Brand: Tocris Bioscience
SKU: 1504

Tocris Bioscience, part of Bio-Techne | Catalog # 1504

Citations (11)

COA / SDS

PDE3 inhibitor

Key Product Details

Description:	PDE3 inhibitor
Chemical Name:	1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	211.22

View Full Technical Details for Milrinone

Technical Data
Citations

Biological Activity for Milrinone

Milrinone is a potent cAMP phosphodiesterase inhibitor (IC₅₀ = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo.

Technical Data for Milrinone

M. Wt	211.22
Formula	C₁₂H₉N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	78415-72-2
PubChem ID	4197
InChi Key	PZRHRDRVRGEVNW-UHFFFAOYSA-N
Smiles	CC1=C(C=C(C#N)C(=O)N1)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Milrinone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.12	100

Preparing Stock Solutions for Milrinone

The following data is based on the product molecular weight 211.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.73 mL	23.67 mL	47.34 mL
5 mM	0.95 mL	4.73 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.73 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

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References for Milrinone

References are publications that support the biological activity of the product.

Shahid The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors. Br.J.Pharmacol. 1991 PMID: 1665737
Tang Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitors. Eur.J.Pharmacol. 1994 PMID: 7925608
Alousi Characterization of the cardiotonic effects of milrinone, a new and potent cardiac bipyridine, on isolated tissues from several animal species. J.Cardiovasc.Pharmacol. 1983 PMID: 6195468