Mirabegron

Name: Mirabegron
Brand: Tocris Bioscience
SKU: 7070

Tocris Bioscience, part of Bio-Techne | Catalog # 7070

Citations (6)

COA / SDS

Potent and selective β3 agonist

Key Product Details

Description:	Potent and selective β₃ agonist
Chemical Name:	2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	396.51

View Full Technical Details for Mirabegron

Technical Data
Citations

Biological Activity for Mirabegron

Mirabegron is a potent and selective β₃-adrenoceptor agonist (EC₅₀ = 22.4 nM). Displays >440-fold selectivity for β₃ over β₁ and β₂ adrenoceptors. Increases cAMP concentration in CHO cells expressing human β₃-adrenoceptor. Displays relaxant effect in ex vivo rat bladder muscle preparation precontracted with carbachol (Cat. No. 2810). Decreases frequency of bladder contraction in rats. Also promotes browning of white adipose tissue, reduces body weight, and improves glucose tolerance and insulin sensitivity in mice fed a high fat diet.

Compound Libraries for Mirabegron

Mirabegron is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Mirabegron

M. Wt	396.51
Formula	C₂₁H₂₄N₄O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	223673-61-8
PubChem ID	9865528
InChi Key	PBAPPPCECJKMCM-IBGZPJMESA-N
Smiles	NC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mirabegron

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.65	100
	ethanol	7.93	20

Preparing Stock Solutions for Mirabegron

The following data is based on the product molecular weight 396.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.50 mL	2.52 mL	5.04 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Mirabegron

References are publications that support the biological activity of the product.

Hao Beneficial metabolic effects of mirabegron in vitro and in high-fat diet-induced obese mice. J.Pharmacol.Exp.Ther. 2019 PMID: 30940691
Sui Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis. Proc.Natl.Acad.Sci.U.S.A. 2019 PMID: 31085638
Takasu Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective β₃-adrenoceptor agonist, on bladder function. J.Pharmacol.Exp.Ther. 2007 PMID: 17293563