ML 145

Tocris Bioscience, part of Bio-Techne | Catalog # 4172

COA / SDS

GPR35 antagonist

Key Product Details

Description:	GPR35 antagonist
Chemical Name:	2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	482.57

View Full Technical Details for ML 145

Technical Data
Citations

Biological Activity for ML 145

ML 145 is a selective antagonist for the GPR35 orphan receptor GPCR (IC₅₀ = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.

Technical Data for ML 145

M. Wt	482.57
Formula	C₂₄H₂₂N₂O₅S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1164500-72-4
PubChem ID	2286812
InChi Key	COFMYJWNXSFLKQ-QIROLCGISA-N
Smiles	O=C(NC3=CC=C(C(O)=O)C(O)=C3)CCCN2C(/C(SC2=S)=C/C(C)=C/C1=CC=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 145

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.26	100

Preparing Stock Solutions for ML 145

The following data is based on the product molecular weight 482.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.36 mL	20.72 mL
5 mM	0.41 mL	2.07 mL	4.14 mL
10 mM	0.21 mL	1.04 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Molarity Calculator

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Reconstitution Calculator

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References for ML 145

References are publications that support the biological activity of the product.

Jenkins Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 2012 PMID: 22967846
Heynen-Genel Antagonists for the orphan receptor GPR35. Probe Reports from the Molecular Libraries Program