ML 184

Name: ML 184
Brand: Tocris Bioscience
SKU: 6668

Tocris Bioscience, part of Bio-Techne | Catalog # 6668

Citations (1)

COA / SDS

Selective GPR55 agonist; also promotes NSC proliferation and differentiation

Key Product Details

Description:	Selective GPR55 agonist; also promotes NSC proliferation and differentiation
Alternative Names:	CID 20440433
Chemical Name:	3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	470.63

View Full Technical Details for ML 184

Technical Data
Citations

Biological Activity for ML 184

ML 184 is a selective GPR55 agonist (EC₅₀ = 250 nM). Exhibits >100-fold selectivity for GPR55 over GPR35, CB₁ and CB₂. Increases proliferation of neural stem cells and promotes neuronal differentiation in vitro.

Compound Libraries for ML 184

ML 184 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for ML 184

M. Wt	470.63
Formula	C₂₅H₃₄N₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	794572-10-4
PubChem ID	2440433
InChi Key	VRSJAHQGJHDACS-UHFFFAOYSA-N
Smiles	CN(S(=O)(C1=CC(C(N2CCN(C3=C(C(C)=CC=C3)C)CC2)=O)=C(N4CCCC4)C=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 184

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.41	20

Preparing Stock Solutions for ML 184

The following data is based on the product molecular weight 470.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.62 mL	53.12 mL	106.24 mL
1 mM	2.12 mL	10.62 mL	21.25 mL
2 mM	1.06 mL	5.31 mL	10.62 mL
10 mM	0.21 mL	1.06 mL	2.12 mL

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References for ML 184

References are publications that support the biological activity of the product.

Kotsikorou Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 2011 PMID: 21534610
Hill Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 2018 PMID: 29888782