ML 334

Name: ML 334
Brand: Tocris Bioscience
SKU: 5625

Tocris Bioscience, part of Bio-Techne | Catalog # 5625

Citations (3)

COA / SDS

Inhibitor of Keap1- Nrf2 interaction

Key Product Details

Description:	Inhibitor of Keap1- Nrf2 interaction
Alternative Names:	LH601A
Chemical Name:	(1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]cyclohexanecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	446.5

View Full Technical Details for ML 334

Technical Data
Citations

Biological Activity for ML 334

ML 334 is an Nrf2 activator; inhibits Nrf2/Keap1 interaction (K_d = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable.

Technical Data for ML 334

M. Wt	446.5
Formula	C₂₆H₂₆N₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1432500-66-7
PubChem ID	56840728
InChi Key	LNENLABLFGGAFF-BHIFYINESA-N
Smiles	O=C([C@@H]1CCCC[C@@H]1C(O)=O)N2CCC3=CC=CC=C3[C@H]2CN4C(C(C=CC=C5)=C5C4=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 334

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.65	100

Preparing Stock Solutions for ML 334

The following data is based on the product molecular weight 446.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.20 mL	22.40 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for ML 334

References are publications that support the biological activity of the product.

Rosini Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 2014 PMID: 24131448
Hu Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 2013 PMID: 23562243