ML 335

Name: ML 335
Brand: Tocris Bioscience
SKU: 6887

Tocris Bioscience, part of Bio-Techne | Catalog # 6887

Citations (3)

COA / SDS

Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

Key Product Details

Chemical Name:	N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for ML 335

ML 335 is a selective K_2P2.1 (TREK-1; KCNK2) and K_2P10.1 (TREK-2; KCNK10) activator (EC₅₀ values of 14.3 μM and 5.2 μM, respectively); directly stimulates the C-type gate via the K_2P modulator pocket. Does not activate K_2P4.1 (TRAAK).

Technical Data for ML 335

Formula	C₁₅H₁₄Cl₂N₂O₃S
Storage	Store at +4°C
Purity	≥98%
CAS Number	825658-06-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 335

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for ML 335

References are publications that support the biological activity of the product.

Schewe et al. A pharmacological master key mechanism that unlocks the selectivity filter gate in K⁺ channels. Science, 2019;363:875 PMID: 30792303
Pope et al. Protein and chemical determinants of BL-1249 action and selectivity for K_2P channels. ACS Chem.Neurosci., 2018;9:3153 PMID: 30089357
Gada et al. Two-pore domain potassium channels: emerging targets for novel analgesic drugs: IUPHAR Review 26. Br.J.Pharmacol., 2019;176:256 PMID: 30325008
Lolicato et al. K_2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature, 2017;547:364 PMID: 28693035

ML 335

Tocris Bioscience, part of Bio-Techne | Catalog # 6887

Key Product Details

Biological Activity for ML 335

Technical Data for ML 335

Solubility for ML 335

Dilution Calculator

Reconstitution Calculator

References for ML 335

Product Documents for ML 335

COA

Certificate of Analysis

SDS

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