ML 337

Name: ML 337
Brand: Tocris Bioscience
SKU: 4982

Tocris Bioscience, part of Bio-Techne | Catalog # 4982

Citations (2)

COA / SDS

Selective negative allosteric modulator of mGlu3 receptors

Key Product Details

Description:	Selective negative allosteric modulator of mGlu₃ receptors
Chemical Name:	[2-Fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	353.39

View Full Technical Details for ML 337

Technical Data
Citations

Biological Activity for ML 337

ML 337 is a selective negative allosteric modulator of mGlu₃ (IC₅₀ = 593 nM). Displays no activity at mGlu₁, mGlu₂ or mGlu_4-8 at concentrations up to 30 μM. Brain penetrant.

Compound Libraries for ML 337

ML 337 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 337

M. Wt	353.39
Formula	C₂₁H₂₀FNO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1443118-44-2
PubChem ID	60204017
InChi Key	QBCRLDPMQHPGIM-QGZVFWFLSA-N
Smiles	O=C(N1CCC[C@@H](O)C1)C(C(F)=C2)=CC=C2C#CC3=CC=C(OC)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 337

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.34	100
	ethanol	7.07	20

Preparing Stock Solutions for ML 337

The following data is based on the product molecular weight 353.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.30 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.41 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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Reconstitution Calculator

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References for ML 337

References are publications that support the biological activity of the product.

Wenthur Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu₃ selective and CNS penetrant negative allosteric modulator (NAM). J.Med.Chem. 2013 PMID: 23718281