MNI caged kainic acid

Name: MNI caged kainic acid
Brand: Tocris Bioscience
SKU: 2225

Tocris Bioscience, part of Bio-Techne | Catalog # 2225

Citations (1)

COA / SDS

Caged kainic acid

Discontinued Product

2225 has been discontinued. View all Caged Compounds products.

Key Product Details

Description:	Caged kainic acid
Chemical Name:	(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid 4-methoxy-7-nitro-1H-indolinyl amide
Purity:	≥99% (HPLC)
Molecular Weight:	389.4

View Full Technical Details for MNI caged kainic acid

Technical Data
Citations

Biological Activity for MNI caged kainic acid

Kainic acid (Cat.No. 0222) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Generates large inward currents at resting membrane potential upon wide field photolysis in Purkinje neurons. Selectively photoactivates kainate receptors when used in conjunction with an AMPA antagonist, such as GYKI 53655 (Cat.No. 2555). Suitable for uncaging with 300-380 nm excitation. Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation. Also suitable for two-photon uncaging experiments at 720 nm.

Licensing Information

Sold under licence from the Medical Research Council

Technical Data for MNI caged kainic acid

M. Wt	389.4
Formula	C₁₉H₂₃N₃O₆
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1315378-75-6
PubChem ID	57414719
InChi Key	IQGCUMUIYXHZOT-AHIWAGSCSA-N
Smiles	C=[C@@](C)[C@@H]1[C@H](CC(N2C(C([N+]([O-])=O)=CC=C3OC)=C3CC2)=O)[C@@H]([C@](O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MNI caged kainic acid

References are publications that support the biological activity of the product.

Palma-Cerda New caged neurotransmitter analogues based on methoxy-nitroindole and nitrophenylethoxycarbonyl caging groups are selective for glutamate receptor subtypes. Neuropharmacology 2013 PMID: 22609535
Passlick and Ellis-Davies Comparative one- and two-photon uncaging of MNI-glutamate and MNI-kainate on hippocampal CA1 neurons. J.Neurosci.Methods. 2017 PMID: 29051090
Maier Comparative analysis of inhibitor effects of caged ligands for the NMDA receptor. J.Neurosci.Meths. 2005 PMID: 15652611