Nalmefene hydrochloride

Name: Nalmefene hydrochloride
Brand: Tocris Bioscience
SKU: 4085

Tocris Bioscience, part of Bio-Techne | Catalog # 4085

Citations (6)

COA / SDS

Opioid receptor antagonist

Key Product Details

Description:	Opioid receptor antagonist
Chemical Name:	(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	375.89

View Full Technical Details for Nalmefene hydrochloride

Technical Data
Citations

Biological Activity for Nalmefene hydrochloride

Nalmefene hydrochloride is an opioid receptor antagonist; displays a longer half life than Naloxone. Exhibits neuroprotective effects after traumatic brain injury in the rat.

Compound Libraries for Nalmefene hydrochloride

Nalmefene hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Nalmefene hydrochloride

M. Wt	375.89
Formula	C₂₁H₂₅NO₃.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	58895-64-0
PubChem ID	5388881
InChi Key	GYWMRGWFQPSQLK-OPHZJPRHSA-N
Smiles	C=C3[C@H]5[C@]24C1=C(O5)C(O)=CC=C1C[C@@H](N(CC6CC6)CC4)[C@@](O)2CC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nalmefene hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	37.59	100
	DMSO	37.59	100

Preparing Stock Solutions for Nalmefene hydrochloride

The following data is based on the product molecular weight 375.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.30 mL	26.60 mL
5 mM	0.53 mL	2.66 mL	5.32 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for Nalmefene hydrochloride

References are publications that support the biological activity of the product.

Vink Opiate antagonist nalmefene improves intracellular free Mg²⁺, bioenergetic state, and neurologic outcome following traumatic brain injury in rats. J.Neurosci. 1990 PMID: 2230942