Naspm trihydrochloride

Name: Naspm trihydrochloride
Brand: Tocris Bioscience
SKU: 2766
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2766

(1)

Citations (43)

COA / SDS

Ca2+-permeable AMPA antagonist

Key Product Details

Description:	Ca²⁺-permeable AMPA antagonist
Alternative Names:	1-Naphthyl acetyl spermine trihydrochloride
Chemical Name:	N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	479.91

View Full Technical Details for Naspm trihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Naspm trihydrochloride

Naspm trihydrochloride is a selective antagonist of Ca²⁺-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.

Technical Data for Naspm trihydrochloride

M. Wt	479.91
Formula	C₂₂H₃₄N₄O.3HCl
Storage	Desiccate at +4°C
Purity	≥97% (HPLC)
CAS Number	1049731-36-3
PubChem ID	16219727
InChi Key	JNEOJAUJWOPWJS-UHFFFAOYSA-N
Smiles	O=C(NCCCNCCCCNCCCN)CC2=CC=CC1=CC=CC=C12.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Naspm trihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	47.99	100

Preparing Stock Solutions for Naspm trihydrochloride

The following data is based on the product molecular weight 479.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.42 mL	20.84 mL
5 mM	0.42 mL	2.08 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for Naspm trihydrochloride

References are publications that support the biological activity of the product.

Noh Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death. Proc.Natl.Acad.Sci.USA
Koike Blocking effect of 1-naphthyl acetyl spermine on Ca²⁺-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci.Res. 1997 PMID: 9293490
Nilsen and England A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 2007 PMID: 17391037
Tsubokawa Effects of spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischaemia. J.Neurophysiol. 1995 PMID: 7472325