NBC 6

Name: NBC 6
Brand: Tocris Bioscience
SKU: 6925
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6925

(1)

Citations (2)

COA / SDS

NLRP3 inflammasome inhibitor

Key Product Details

Description:	NLRP3 inflammasome inhibitor
Chemical Name:	(T4)-[2-Acetyl-4,4,4-trichloro-3-(imino-κN)butanamidito-κO]diphenylboron
Purity:	≥98% (HPLC)
Molecular Weight:	409.5

View Full Technical Details for NBC 6

Technical Data
Citations / Reviews (1)

Biological Activity for NBC 6

NBC 6 is a NLRP3 inflammasome inhibitor (IC₅₀ = 574 nM). Inhibits nigericin-induced inflammasome activation in THP-1 cells and Imiquimod (Cat. No. 3700) induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs).

Licensing Information

Sold under license from the University of Manchester.

Technical Data for NBC 6

M. Wt	409.5
Formula	C₁₈H₁₆BCl₃N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2068818-02-8
PubChem ID	145237739
InChi Key	VKECODDKRKQJNM-UHFFFAOYSA-N
Smiles	CC(C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBC 6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.95	100
	ethanol	2.05	5

Preparing Stock Solutions for NBC 6

The following data is based on the product molecular weight 409.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.21 mL	24.42 mL
5 mM	0.49 mL	2.44 mL	4.88 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for NBC 6

References are publications that support the biological activity of the product.

Baldwin Boron-based inhibitors of the NLRP3 inflammasome. Cell Chem.Biol. 2017 PMID: 28943355