NCL 00017509

Name: NCL 00017509
Brand: Tocris Bioscience
SKU: 5150

Tocris Bioscience, part of Bio-Techne | Catalog # 5150

Citations (2)

COA / SDS

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor

Key Product Details

Description:	Potent and reversible NIMA related kinase 2 (Nek2) inhibitor
Chemical Name:	3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
Purity:	≥97% (HPLC)
Molecular Weight:	292.3

View Full Technical Details for NCL 00017509

Technical Data
Citations

Biological Activity for NCL 00017509

NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC₅₀ = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.

Technical Data for NCL 00017509

M. Wt	292.3
Formula	C₁₅H₁₂N₆O
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	1507367-00-1
PubChem ID	56944360
InChi Key	CJQGLUJHMXCLQY-UHFFFAOYSA-N
Smiles	C#CC1=C2C(NC=N2)=NC(NC3=CC=CC(CC(N)=O)=C3)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NCL 00017509

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.23	100

Preparing Stock Solutions for NCL 00017509

The following data is based on the product molecular weight 292.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.11 mL	34.21 mL
5 mM	0.68 mL	3.42 mL	6.84 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References for NCL 00017509

References are publications that support the biological activity of the product.

Zhang NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat.Commun. 2021 PMID: 34315872
Lebraud Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 2014 PMID: 24213855