Neuropeptide FF

Name: Neuropeptide FF
Brand: Tocris Bioscience
SKU: 3137

Tocris Bioscience, part of Bio-Techne | Catalog # 3137

Citations (7)

COA / SDS

Endogenous NPFF1 and NPFF2 agonist; also MRGPRA agonist

Key Product Details

Description:	Endogenous NPFF₁ and NPFF₂ agonist; also MRGPRA agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1081.28

View Full Technical Details for Neuropeptide FF

Technical Data
Citations

Biological Activity for Neuropeptide FF

Neuropeptide FF is an endogenous antiopioid peptide and agonist at NPFF₁ and NPFF₂ receptors (K_i values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects following i.c.v. administration. Also MRGPRA agonist.

Technical Data for Neuropeptide FF

M. Wt	1081.28
Formula	C₅₄H₇₆N₁₄O₁₀
Single Letter Sequence	FLFQPQRF (Modifications: Phe-8 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	99566-27-5
PubChem ID	9854861
InChi Key	HWYCFZUSOBOBIN-AQJXLSMYSA-N
Smiles	[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Neuropeptide FF

Solubility

Soluble to 0.5mg/ml in water

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References for Neuropeptide FF

References are publications that support the biological activity of the product.

Gouarderes Functional differences between NPFF₁ and NPFF₂ receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of[³⁵S]GTPγS binding. Neuropharmacology 2007 PMID: 17011599
Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Cline Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks. Neuropeptides 2007 PMID: 17936900