NIBR 189

Name: NIBR 189
Brand: Tocris Bioscience
SKU: 5203

Tocris Bioscience, part of Bio-Techne | Catalog # 5203

Citations (9)

COA / SDS

Potent and selective EBI2 (GPR183) receptor antagonist

Key Product Details

Description:	Potent and selective EBI2 (GPR183) receptor antagonist
Chemical Name:	(2E)-3-(4-Bromophenyl)-1-[4-4-methoxybenzoyl)-1-piperazinyl]-2-propene-1-one
Purity:	≥99% (HPLC)
Molecular Weight:	429.31

View Full Technical Details for NIBR 189

Technical Data
Citations

Biological Activity for NIBR 189

NIBR 189 is a potent and selective EBI2 (GPR183) receptor antagonist (IC₅₀ values are 11 and 15 nM for human and mouse EBI2 receptors respectively). Exhibits selectivity for EBI2 over a panel of other receptors, enzymes and transporters. Blocks oxysterol-induced migration of U937 monocyte cells. Orally bioavailable.

Technical Data for NIBR 189

M. Wt	429.31
Formula	C₂₁H₂₁BrN₂O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1599432-08-2
PubChem ID	36295259
InChi Key	OFHXXBRBGWUOHR-NYYWCZLTSA-N
Smiles	BrC1=CC=C(/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NIBR 189

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.93	100

Preparing Stock Solutions for NIBR 189

The following data is based on the product molecular weight 429.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.65 mL	23.29 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for NIBR 189

References are publications that support the biological activity of the product.

Gessier Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J.Med.Chem. 2014 PMID: 24678947