Nisoxetine hydrochloride

Name: Nisoxetine hydrochloride
Brand: Tocris Bioscience
SKU: 1025

Tocris Bioscience, part of Bio-Techne | Catalog # 1025

Citations (19)

COA / SDS

Noradrenalin re-uptake inhibitor

Key Product Details

Description:	Noradrenalin re-uptake inhibitor
Chemical Name:	(±)-γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	307.82

View Full Technical Details for Nisoxetine hydrochloride

Technical Data
Citations

Biological Activity for Nisoxetine hydrochloride

Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.

Technical Data for Nisoxetine hydrochloride

M. Wt	307.82
Formula	C₁₇H₂₁NO₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	57754-86-6
PubChem ID	134453
InChi Key	LCEURBZEQJZUPV-UHFFFAOYSA-N
Smiles	Cl.CNCCC(OC1=CC=CC=C1OC)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nisoxetine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	30.78	100

Preparing Stock Solutions for Nisoxetine hydrochloride

The following data is based on the product molecular weight 307.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.24 mL	32.49 mL
5 mM	0.65 mL	3.25 mL	6.50 mL
10 mM	0.32 mL	1.62 mL	3.25 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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References for Nisoxetine hydrochloride

References are publications that support the biological activity of the product.

Zhu Down-regulation of NE transporters on PC12 cells by transporter inhibitors. J.Neurochem. 1997 PMID: 8978719
Shearman and Meyer NE transporters in rat placenta labeled with [³H]nisoxetine. J.Pharmacol.Exp.Ther. 1998 PMID: 9454822
Wong dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of NE into rat brain synaptosomes and heart. Life Sci. 1975 PMID: 1207394
Cheetham [³H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [³H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 1996 PMID: 8684598