NNC 55-0396 dihydrochloride

Name: NNC 55-0396 dihydrochloride
Brand: Tocris Bioscience
SKU: 2268

Tocris Bioscience, part of Bio-Techne | Catalog # 2268

Citations (23)

COA / SDS

Highly selective CaV3.x blocker

Key Product Details

Description:	Highly selective Ca_V3.x blocker
Chemical Name:	(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	564.57

View Full Technical Details for NNC 55-0396 dihydrochloride

Technical Data
Citations

Biological Activity for NNC 55-0396 dihydrochloride

NNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker. Displays IC₅₀ values of 6.8 and > 100 μM for inhibition of Ca_v3.1 T-type channels and HVA currents respectively in INS-1 cells.

Technical Data for NNC 55-0396 dihydrochloride

M. Wt	564.57
Formula	C₃₀H₃₈FN₃O₂.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	357400-13-6
PubChem ID	22084904
InChi Key	BCCQNBXHUMKLFW-HNQRYHMESA-N
Smiles	FC1=CC(CC[C@@](CCN(C)CCCC3=NC(C=CC=C5)=C5N3)(OC(C4CC4)=O)[C@H]2[C@H](C)C)=C2C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NNC 55-0396 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	14.11	25

Preparing Stock Solutions for NNC 55-0396 dihydrochloride

The following data is based on the product molecular weight 564.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	7.09 mL	35.43 mL	70.85 mL
1.25 mM	1.42 mL	7.09 mL	14.17 mL
2.5 mM	0.71 mL	3.54 mL	7.09 mL
12.5 mM	0.14 mL	0.71 mL	1.42 mL

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References for NNC 55-0396 dihydrochloride

References are publications that support the biological activity of the product.

Chen Ca_V3.2 T-type Ca²⁺ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 2010 PMID: 20685979
Huang NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha J.Pharmacol.Exp.Ther. 2004 PMID: 14718587