NS 3861

Name: NS 3861
Brand: Tocris Bioscience
SKU: 4831

Tocris Bioscience, part of Bio-Techne | Catalog # 4831

Citations (5)

COA / SDS

α3β2 full agonist; also α3β4 partial agonist

Key Product Details

Description:	α3β2 full agonist; also α3β4 partial agonist
Chemical Name:	3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate
Purity:	≥98% (HPLC)
Molecular Weight:	400.29

View Full Technical Details for NS 3861

Technical Data
Citations

Biological Activity for NS 3861

NS 3861 is a α3β2 full agonist (EC₅₀ = 1.6 μM). Also α3β4 partial agonist (EC₅₀ = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (K_i values are 0.62, 7.8, 25 and 55 nM respectively).

Technical Data for NS 3861

M. Wt	400.29
Formula	C₁₂H₁₄BrNS.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	216853-60-0
PubChem ID	91826078
InChi Key	KXBSQPLWTVQFGJ-WLHGVMLRSA-N
Smiles	CN1C2CCC1CC(C3=C(Br)C=CS3)=C2.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 3861

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.01	50
	DMSO	40.03	100

Preparing Stock Solutions for NS 3861

The following data is based on the product molecular weight 400.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.98 mL
5 mM	0.50 mL	2.50 mL	5.00 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for NS 3861

References are publications that support the biological activity of the product.

Harpsøe Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 2013 PMID: 23229547