NSC 624206

Name: NSC 624206
Brand: Tocris Bioscience
SKU: 4993

Tocris Bioscience, part of Bio-Techne | Catalog # 4993

Citations (2)

COA / SDS

Ubiquitin-activating enzyme (E1) inhibitor

Key Product Details

Description:	Ubiquitin-activating enzyme (E1) inhibitor
Chemical Name:	N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	410.51

View Full Technical Details for NSC 624206

Technical Data
Citations

Biological Activity for NSC 624206

NSC 624206 is an ubiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.

Technical Data for NSC 624206

M. Wt	410.51
Formula	C₁₉H₃₂ClNS₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	13116-77-3
PubChem ID	361263
InChi Key	JQHUAYXPNPTQRO-UHFFFAOYSA-N
Smiles	ClC1=CC=C(CSSCCNCCCCCCCCCC)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 624206

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.53	50
	ethanol	8.21	20

Preparing Stock Solutions for NSC 624206

The following data is based on the product molecular weight 410.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.87 mL	24.36 mL	48.72 mL
2.5 mM	0.97 mL	4.87 mL	9.74 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
25 mM	0.10 mL	0.49 mL	0.97 mL

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References for NSC 624206

References are publications that support the biological activity of the product.

Ungermannova Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J.Biomol.Screen. 2012 PMID: 22274912