nTZDpa

Name: nTZDpa
Brand: Tocris Bioscience
SKU: 2150

Tocris Bioscience, part of Bio-Techne | Catalog # 2150

Citations (2)

COA / SDS

Potent, selective PPARγ partial agonist

Key Product Details

Description:	Potent, selective PPARγ partial agonist
Chemical Name:	5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	428.33

View Full Technical Details for nTZDpa

Technical Data
Citations

Biological Activity for nTZDpa

nTZDpa is a potent, selective non-thiazolidinedione PPARγ partial agonist (EC₅₀ = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC₅₀ ~ 285 nM). Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo.

Technical Data for nTZDpa

M. Wt	428.33
Formula	C₂₂H₁₅Cl₂NO₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	118414-59-8
PubChem ID	9954280
InChi Key	VUPOTURDKDMIGQ-UHFFFAOYSA-N
Smiles	OC(=O)C1=C(SC2=CC=CC=C2)C2=CC(Cl)=CC=C2N1CC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for nTZDpa

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.83	100

Preparing Stock Solutions for nTZDpa

The following data is based on the product molecular weight 428.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.67 mL	23.35 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for nTZDpa

References are publications that support the biological activity of the product.

Berger Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator. Mol.Endocrinol. 2003 PMID: 12554792