NVS PAK1 C

Name: NVS PAK1 C
Brand: Tocris Bioscience
SKU: 6133

Tocris Bioscience, part of Bio-Techne | Catalog # 6133

COA / SDS

Negative control of NVS PAK1 1 (Cat. No. 6132)

Key Product Details

Description:	Negative control of NVS PAK1 1 (Cat. No. 6132)
Chemical Name:	(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N,N-dimethylpyrrolidine-1-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	465.91

View Full Technical Details for NVS PAK1 C

Technical Data
Citations

Biological Activity for NVS PAK1 C

NVS PAK1 C is a negative control of NVS PAK1 1 (Cat. No. 6132), a potent and selective PAK1 inhibitor.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS PAK1 1 probe summary on the SGC website.

Technical Data for NVS PAK1 C

M. Wt	465.91
Formula	C₂₂H₂₃ClF₃N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2250019-95-3
PubChem ID	136590564
InChi Key	RVHZFZVJXGIAJF-HNNXBMFYSA-N
Smiles	FC(F)CN(C(C=CC(F)=C1)=C1N=C2N[C@H]3CCN(C(N(C)C)=O)C3)C4=C2C=C(Cl)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NVS PAK1 C

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.59	100
	ethanol	9.32	20

Preparing Stock Solutions for NVS PAK1 C

The following data is based on the product molecular weight 465.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.46 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for NVS PAK1 C

References are publications that support the biological activity of the product.

Karpov Optimization of a dibenzodiazepine hit to a potent and selective allosteric PAK1 inhibitor. ACS Med.Chem.Lett 2015 PMID: 26191365