OG-L002

Name: OG-L002
Brand: Tocris Bioscience
SKU: 6244

Tocris Bioscience, part of Bio-Techne | Catalog # 6244

Citations (7)

COA / SDS

Potent LSD1 inhibitor

Key Product Details

Description:	Potent LSD1 inhibitor
Chemical Name:	4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol
Purity:	≥98% (HPLC)
Molecular Weight:	225.29

View Full Technical Details for OG-L002

Technical Data
Citations

Biological Activity for OG-L002

OG-L002 is a potent LSD1 inhibitor (IC₅₀ = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC₅₀ values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.

Technical Data for OG-L002

M. Wt	225.29
Formula	C₁₅H₁₅NO
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1357302-64-7
PubChem ID	56639570
InChi Key	DSOJSZXQRJGBCW-CABCVRRESA-N
Smiles	N[C@H]1C[C@@H]1C2=CC=C(C3=CC(O)=CC=C3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OG-L002

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.53	100
	ethanol	22.53	100
	1eq. HCl	4.51	20

Preparing Stock Solutions for OG-L002

The following data is based on the product molecular weight 225.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.44 mL	22.19 mL	44.39 mL
5 mM	0.89 mL	4.44 mL	8.88 mL
10 mM	0.44 mL	2.22 mL	4.44 mL
50 mM	0.09 mL	0.44 mL	0.89 mL

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References for OG-L002

References are publications that support the biological activity of the product.

Liang A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 2013 PMID: 23386436