Oltipraz

Name: Oltipraz
Brand: Tocris Bioscience
SKU: 5294

Tocris Bioscience, part of Bio-Techne | Catalog # 5294

Citations (2)

COA / SDS

Nrf2 activator

Key Product Details

Description:	Nrf2 activator
Chemical Name:	4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
Purity:	≥99% (HPLC)
Molecular Weight:	226.34

View Full Technical Details for Oltipraz

Technical Data
Citations

Biological Activity for Oltipraz

Oltipraz is a Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.

Technical Data for Oltipraz

M. Wt	226.34
Formula	C₈H₆N₂S₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	64224-21-1
PubChem ID	47318
InChi Key	CKNAQFVBEHDJQV-UHFFFAOYSA-N
Smiles	CC1=C(SSC1=S)C2=CN=CC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oltipraz

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.32	50

Preparing Stock Solutions for Oltipraz

The following data is based on the product molecular weight 226.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.84 mL	44.18 mL	88.36 mL
2.5 mM	1.77 mL	8.84 mL	17.67 mL
5 mM	0.88 mL	4.42 mL	8.84 mL
25 mM	0.18 mL	0.88 mL	1.77 mL

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References for Oltipraz

References are publications that support the biological activity of the product.

Manandhar Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. Eur J Pharmacol. 2007 PMID: 17854798
Maher Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology 2007 PMID: 17668877
Merrell Induction of drug metabolism enzymes and transporters by oltipraz in rats. J.Biochem.Mol.Toxicol. 2008 PMID: 18418891