Ononetin

Name: Ononetin
Brand: Tocris Bioscience
SKU: 5143

Tocris Bioscience, part of Bio-Techne | Catalog # 5143

Citations (12)

COA / SDS

TRPM3 blocker

Key Product Details

Description:	TRPM3 blocker
Chemical Name:	1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
Purity:	≥98% (HPLC)
Molecular Weight:	258.27

View Full Technical Details for Ononetin

Technical Data
Citations

Biological Activity for Ononetin

Ononetin is a naturally occurring deoxybenzoin. TRPM3 channel blocker (IC₅₀ = 300 nM). Inhibits pregnenolone sulfate-induced intracellular Ca²⁺ accumulation in HEK_mTRPM3 cells and dorsal root ganglia (DRG) neurons in vitro.

Technical Data for Ononetin

M. Wt	258.27
Formula	C₁₅H₁₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	487-49-0
PubChem ID	259632
InChi Key	XHBZOAYMBBUURD-UHFFFAOYSA-N
Smiles	COC1=CC=C(CC(C2=C(O)C=C(O)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ononetin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.83	100
	ethanol	25.83	100

Preparing Stock Solutions for Ononetin

The following data is based on the product molecular weight 258.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.87 mL	19.36 mL	38.72 mL
5 mM	0.77 mL	3.87 mL	7.74 mL
10 mM	0.39 mL	1.94 mL	3.87 mL
50 mM	0.08 mL	0.39 mL	0.77 mL

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Reconstitution Calculator

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References for Ononetin

References are publications that support the biological activity of the product.

Straub Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br.J.Pharmacol. 2012 PMID: 23190005