Org 25543 hydrochloride

Name: Org 25543 hydrochloride
Brand: Tocris Bioscience
SKU: 4782

Tocris Bioscience, part of Bio-Techne | Catalog # 4782

Citations (3)

COA / SDS

Potent and selective GlyT2 inhibitor

Key Product Details

Description:	Potent and selective GlyT2 inhibitor
Chemical Name:	N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	448.98

View Full Technical Details for Org 25543 hydrochloride

Technical Data
Citations

Biological Activity for Org 25543 hydrochloride

Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC₅₀ = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.

Compound Libraries for Org 25543 hydrochloride

Org 25543 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Org 25543 hydrochloride

M. Wt	448.98
Formula	C₂₄H₃₂lN₂O₄.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	495076-64-7
PubChem ID	10095215
InChi Key	NIPQJILJYQVZJR-UHFFFAOYSA-N
Smiles	O=C(NCC2(N(C)C)CCCC2)C1=CC(OC)=C(OCC3=CC=CC=C3)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Org 25543 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	8.98	20
	DMSO	44.9	100

Preparing Stock Solutions for Org 25543 hydrochloride

The following data is based on the product molecular weight 448.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.14 mL	22.27 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for Org 25543 hydrochloride

References are publications that support the biological activity of the product.

Morita Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 2008 PMID: 18448867
Caulfield The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 2001 PMID: 11495577