OSU 6162 hydrochloride

Name: OSU 6162 hydrochloride
Brand: Tocris Bioscience
SKU: 2599

Tocris Bioscience, part of Bio-Techne | Catalog # 2599

Citations (2)

COA / SDS

Dopamine stabilizer

Key Product Details

Chemical Name:	(3S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
Purity:	≥98%
Molecular Weight:	317.87 kDa

View Full Technical Details for OSU 6162 hydrochloride

Technical Data
Citations

Biological Activity for OSU 6162 hydrochloride

OSU 6162 hydrochloride is a dopamine stabilizer; lacks high affinity for various neuroreceptors in vitro (K_i values are 447 and 1305 nM for D₂ and D₃ receptors respectively and > 1 μM for other targets). Exhibits high D₂ receptor occupancy in vivo; highly active on dopamine synthesis and turnover. Induces stabilizing effects on psychomotor function in behavioral tests without inducing hypolocomotion or catalepsy.

Technical Data for OSU 6162 hydrochloride

M. Wt	317.87 kDa
Formula	C₁₅H₂₃NO₂S.HCl
Storage	Store at +4°C
Purity	≥98%
CAS Number	156907-84-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OSU 6162 hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for OSU 6162 hydrochloride

References are publications that support the biological activity of the product.

Nichols et al. PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by DA agonists in a rat model for Parkinson's disease. Neuropharmacology, 2002;43:817 PMID: 12384167
Rung et al. The DArgic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats. Prog.Neuro-Psychopharm.Biol.Psychiat., 2005;29:833
Natesan et al. The DA stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonyl-phenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potentia J.Pharmacol.Exp.Ther., 2006;318:810 PMID: 16648369