Oxotremorine M

Name: Oxotremorine M
Brand: Tocris Bioscience
SKU: 1067

Tocris Bioscience, part of Bio-Techne | Catalog # 1067

Citations (68)

COA / SDS

Muscarinic agonist

Key Product Details

Description:	Muscarinic agonist
Chemical Name:	N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide
Purity:	≥98% (HPLC)
Molecular Weight:	322.19

View Full Technical Details for Oxotremorine M

Technical Data
Citations

Biological Activity for Oxotremorine M

Oxotremorine M is a muscarinic receptor agonist. Also directly potentiates NMDA-mediated ion currents.

Technical Data for Oxotremorine M

M. Wt	322.19
Formula	C₁₁H₁₉IN₂O
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	3854-04-4
PubChem ID	3027782
InChi Key	VVLMSCJCXMBGDI-UHFFFAOYSA-M
Smiles	O=C1N(CC#CC[N+](C)(C)C)CCC1.[I-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oxotremorine M

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	32.22	100

Preparing Stock Solutions for Oxotremorine M

The following data is based on the product molecular weight 322.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.10 mL	15.52 mL	31.04 mL
5 mM	0.62 mL	3.10 mL	6.21 mL
10 mM	0.31 mL	1.55 mL	3.10 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for Oxotremorine M

References are publications that support the biological activity of the product.

Kukkonen Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system. J.Pharmacol.Exp.Ther. 1996 PMID: 8930161
Zwart Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. Biochem.Biophys.Res.Commun. 2017 PMID: 29127015
Birdsall The binding of agonists to brain muscarinic receptors. Mol.Pharmacol. 1978 PMID: 714021