P7C3

Name: P7C3
Brand: Tocris Bioscience
SKU: 4076

Tocris Bioscience, part of Bio-Techne | Catalog # 4076

Citations (5)

COA / SDS

NAMPT activator; also proneurogenic and neuroprotective

Key Product Details

Description:	NAMPT activator; also proneurogenic and neuroprotective
Chemical Name:	3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
Purity:	≥99% (HPLC)
Molecular Weight:	474.19

View Full Technical Details for P7C3

Technical Data
Citations

Biological Activity for P7C3

P7C3 is a NAMPT activator. Proneurogenic and neuroprotective. Protects newborn neurons in the dentate gyrus by mitigating cell death. Also enhances learning and memory in aged rats. Orally available and brain penetrant. Also revents doxorubicin-mediated toxicity in osteosarcoma cells and restores intracellular NAD levels.

Compound Libraries for P7C3

P7C3 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for P7C3

M. Wt	474.19
Formula	C₂₁H₁₈Br₂N₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	301353-96-8
PubChem ID	2836187
InChi Key	FZHHRERIIVOATI-UHFFFAOYSA-N
Smiles	BrC(C=C3)=CC1=C3N(CC(O)CNC4=CC=CC=C4)C2=C1C=C(Br)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for P7C3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.42	100

Preparing Stock Solutions for P7C3

The following data is based on the product molecular weight 474.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.11 mL	10.54 mL	21.09 mL
5 mM	0.42 mL	2.11 mL	4.22 mL
10 mM	0.21 mL	1.05 mL	2.11 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for P7C3

References are publications that support the biological activity of the product.

Wang P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 2014 PMID: 25215490
Pieper Discovery of a proneurogenic, neuroprotective chemical. Cell 2010 PMID: 20603013