PD 168568 dihydrochloride

Name: PD 168568 dihydrochloride
Brand: Tocris Bioscience
SKU: 3529

Tocris Bioscience, part of Bio-Techne | Catalog # 3529

Citations (2)

COA / SDS

Potent and selective D4 antagonist

Key Product Details

Description:	Potent and selective D₄ antagonist
Chemical Name:	3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	422.39

View Full Technical Details for PD 168568 dihydrochloride

Technical Data
Citations

Biological Activity for PD 168568 dihydrochloride

PD 168568 dihydrochloride is a potent and selective dopamine D₄ receptor antagonist (K_i values are 8.8 and 1842 nM at D₄ and D₂ receptors respectively). Reverses amphetamine-stimulated locomotion in vivo and is orally active.

Technical Data for PD 168568 dihydrochloride

M. Wt	422.39
Formula	C₂₂H₂₇N₃O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1782532-06-2
PubChem ID	56972231
InChi Key	RMNWLEGGYCVHFD-UHFFFAOYSA-N
Smiles	CC1=C(C)C=CC(N2CCN(CCC(N4)C3=CC=CC=C3C4=O)CC2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PD 168568 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	21.12	50
	DMSO	42.24	100

Preparing Stock Solutions for PD 168568 dihydrochloride

The following data is based on the product molecular weight 422.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.84 mL	23.67 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for PD 168568 dihydrochloride

References are publications that support the biological activity of the product.

Belliotti Isoindolinone enantiomers having affinity for the DA D₄ receptor. Bioorg.Med.Chem.Lett. 1998 PMID: 9873377