pep2-SVKI

Name: pep2-SVKI
Brand: Tocris Bioscience
SKU: 1597

Tocris Bioscience, part of Bio-Techne | Catalog # 1597

COA / SDS

Peptide inhibitor of GluA2 subunit binding to GRIP, ABP and PICK1; increases AMPA current amplitude

Discontinued Product

1597 has been discontinued. View all AMPA Receptor Inhibitors products.

Key Product Details

Description:	Peptide inhibitor of GluA2 subunit binding to GRIP, ABP and PICK1; increases AMPA current amplitude
Molecular Weight:	1284.47

View Full Technical Details for pep2-SVKI

Technical Data
Citations

Biological Activity for pep2-SVKI

pep2-SVKI is an inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).

Control Peptide also available.

Technical Data for pep2-SVKI

M. Wt	1284.47
Formula	C₆₀H₉₃N₁₃O₁₈
Single Letter Sequence	YNVYGIESVKI
Storage	Desiccate at -20°C
CAS Number	328944-75-8
PubChem ID	90479807
InChi Key	YWTNLHXVGSIPEM-YDSVATBTSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for pep2-SVKI

References are publications that support the biological activity of the product.

Li AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 1999 PMID: 10526335
Daw PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 2000 PMID: 11163273
Kim Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 2001 PMID: 11573007
Collingridge and Isaac Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 2003 PMID: 12941441

pep2-SVKI

Tocris Bioscience, part of Bio-Techne | Catalog # 1597

Key Product Details

Biological Activity for pep2-SVKI

Technical Data for pep2-SVKI

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for pep2-SVKI

Product Documents for pep2-SVKI

COA

Certificate of Analysis

SDS

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