Pertussis Toxin

Name: Pertussis Toxin
Brand: Tocris Bioscience
SKU: 3097
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3097

(2)

Citations (219)

COA / SDS

Catalyzes ADP-ribosylation of Gi, Go and Gt

Key Product Details

Description:

Catalyzes ADP-ribosylation of G_i, G_o and G_t

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Technical Data
Citations / Reviews (2)

Biological Activity for Pertussis Toxin

Pertussis Toxin is a bacterial toxin that catalyzes ADP-ribosylation of G-proteins G_i, G_o and G_t. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling. Pertussis Toxin protects against ischemic stroke in a mouse model of permanent middle cerebral artery occlusion. Pertussis Toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an experimental autoimmune encephalomyelitis mouse model.

Technical Data for Pertussis Toxin

Storage	Store at +4°C
CAS Number	70323-44-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Pertussis Toxin

References are publications that support the biological activity of the product.

Yin Centrally administered pertussis toxin inhibits microglia migration to the spinal cord and prevents dissemination of disease in an EAE mouse model. PLoS One 2010 PMID: 20811645
Tang Pertussis toxin reduces calcium influx to protect ischemic stroke in a middle cerebral artery occlusion model. J.Neurochem. 2015 PMID: 26365274
Barbieri and Cortina ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. Infect.Immun. 1988 PMID: 3135265
Casey G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with G_sa. Biochemistry 1989 PMID: 2496748
Bokoch Indentification of the predominant substrate for ADP-ribosylation by islet activating protein. J.Biol.Chem. 1983 PMID: 6296122

Pertussis Toxin

Tocris Bioscience, part of Bio-Techne | Catalog # 3097

Key Product Details

Biological Activity for Pertussis Toxin

Technical Data for Pertussis Toxin

Dilution Calculator

Reconstitution Calculator

References for Pertussis Toxin

Product Documents for Pertussis Toxin

COA

Certificate of Analysis

SDS

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