PF 06726304 acetate

Name: PF 06726304 acetate
Brand: Tocris Bioscience
SKU: 6169

Tocris Bioscience, part of Bio-Techne | Catalog # 6169

Citations (1)

COA / SDS

Highly potent and SAM-competitive EZH2 inhibitor

Key Product Details

Description:	Highly potent and SAM-competitive EZH2 inhibitor
Chemical Name:	5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
Purity:	≥97% (HPLC)
Molecular Weight:	506.38

View Full Technical Details for PF 06726304 acetate

Technical Data
Citations

Biological Activity for PF 06726304 acetate

PF 06726304 acetate is a highly potent and SAM-competitive EZH2 lysine methyltransferase inhibitor (IC₅₀ = 0.7 nM). Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, and halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 06726304 acetate

M. Wt	506.38
Formula	C₂₂H₂₁Cl₂N₃O₃.C₂H₄O₂
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	2080306-28-9
PubChem ID	124201861
InChi Key	AVDCFFPRJKOOLX-UHFFFAOYSA-N
Smiles	ClC1=C(C(N(CC2=C(C)C=C(C)NC2=O)CC3)=O)C3=C(Cl)C=C1C4=C(C)ON=C4C.CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 06726304 acetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.64	100
	ethanol	50.64	100

Preparing Stock Solutions for PF 06726304 acetate

The following data is based on the product molecular weight 506.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.87 mL	19.75 mL
5 mM	0.39 mL	1.97 mL	3.95 mL
10 mM	0.20 mL	0.99 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for PF 06726304 acetate

References are publications that support the biological activity of the product.

Kung Design and synthesis of pyridone-containing 3,4-dihydroisoquinoline-1(2H)-ones as a novel class of enhancer of zeste homolog 2 (EZH2) inhibitors. J.Med.Chem. 2016 PMID: 27512831