PF 945863

Name: PF 945863
Brand: Tocris Bioscience
SKU: 4419
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4419

(1)

COA / SDS

Macrolide antibiotic

Discontinued Product

4419 has been discontinued. View all Antibiotics products.

Key Product Details

Description:	Macrolide antibiotic
Chemical Name:	(3aS,4R,7R,9R,10R,11R,13R,15R,15aR)-4-Ethyloctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-1-[1-[(1R)-1-(1,8-naphthyridin-4-yl)ethyl]-3-azetidinyl]-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)tetrone
Purity:	≥98% (HPLC)
Molecular Weight:	824.01

View Full Technical Details for PF 945863

Technical Data
Citations / Reviews (1)

Biological Activity for PF 945863

PF 945863 is a macrolide antibiotic. Active against multidrug resistant respiratory tract bacterial strains. Does not have the hepatotoxic side effects associated with telithromycin. Orally active.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 945863

M. Wt	824.01
Formula	C₄₄H₆₅N₅O₁₀
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	893556-85-9
PubChem ID	90488939
InChi Key	FATPJRUUPNLGGR-ACVHMLGSSA-N
Smiles	O=C(N2C3CN([C@H](C)C4=C(C=CC=N5)C5=NC=C4)C3)O[C@](C2[C@H]1C)(C)[C@@H](CC)OC([C@H](C)C([C@H](C)[C@@H](O[C@@]6([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O6)[C@](C)(OC)C[C@@H](C)C1=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PF 945863

References are publications that support the biological activity of the product.

Zientek In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab.Dispos. 2010 PMID: 20444863
Magee Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J.Med.Chem. 2009 PMID: 19775168