PFK 15

Name: PFK 15
Brand: Tocris Bioscience
SKU: 5339

Tocris Bioscience, part of Bio-Techne | Catalog # 5339

Citations (2)

COA / SDS

Selective PFKFB3 inhibitor

Key Product Details

Chemical Name:	1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Purity:	≥99%

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Technical Data
Citations

Biological Activity for PFK 15

PFK 15 is originally reported to be a selective PFKFB3 inhibitor (IC₅₀ = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay. Selective for PFKFB3 over a panel of 96 kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.

Technical Data for PFK 15

Formula	C₁₇H₁₂N₂O
Storage	Store at -20°C
Purity	≥99%
CAS Number	4382-63-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PFK 15

Solubility

Soluble Soluble to 100 mM in DMSO

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References for PFK 15

References are publications that support the biological activity of the product.

Brooke et al. Targeting the Warburg effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). Bioorg.Med.Chem., 2014;22:1029 PMID: 24398380
Clem et al. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol.Cancer Ther., 2013;12:1461 PMID: 23674815

PFK 15

Tocris Bioscience, part of Bio-Techne | Catalog # 5339

Key Product Details

Biological Activity for PFK 15

Technical Data for PFK 15

Solubility for PFK 15

Dilution Calculator

Reconstitution Calculator

References for PFK 15

Product Documents for PFK 15

COA

Certificate of Analysis

SDS

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