PH 797804

Name: PH 797804
Brand: Tocris Bioscience
SKU: 5866

Tocris Bioscience, part of Bio-Techne | Catalog # 5866

Citations (3)

COA / SDS

Potent and selective p38α/β inhibitor

Key Product Details

Description:	Potent and selective p38α/β inhibitor
Chemical Name:	(-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	477.3

View Full Technical Details for PH 797804

Technical Data
Citations

Biological Activity for PH 797804

PH 797804 is a potent and selective p38α/β inhibitor (IC₅₀ values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active.

PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for PH 797804

PH 797804 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for PH 797804

M. Wt	477.3
Formula	C₂₂H₁₉BrF₂N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1358027-80-1
PubChem ID	22049997
InChi Key	KCAJXIDMCNPGHZ-UHFFFAOYSA-N
Smiles	FC1=CC=C(COC2=C(Br)C(N(C3=CC(C(NC)=O)=CC=C3C)C(C)=C2)=O)C(F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PH 797804

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.86	50

Preparing Stock Solutions for PH 797804

The following data is based on the product molecular weight 477.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.19 mL	20.95 mL	41.90 mL
2.5 mM	0.84 mL	4.19 mL	8.38 mL
5 mM	0.42 mL	2.10 mL	4.19 mL
25 mM	0.08 mL	0.42 mL	0.84 mL

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References for PH 797804

References are publications that support the biological activity of the product.

Selness Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg.Med.Chem.Lett. 2011 PMID: 21641211
Hope Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J.Pharmacol.Exp.Ther. 2009 PMID: 19720877