PHA 543613 hydrochloride

Name: PHA 543613 hydrochloride
Brand: Tocris Bioscience
SKU: 3092
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3092

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Citations (18)

COA / SDS

Potent and selective α7 nAChR agonist

Key Product Details

Description:	Potent and selective α7 nAChR agonist
Chemical Name:	N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	307.78

View Full Technical Details for PHA 543613 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for PHA 543613 hydrochloride

PHA 543613 hydrochloride is a potent α7 nAChR agonist that displays selectivity over α3β4, α1β1γδ, α4β2 and 5-HT₃ receptors. Positively influences sensory gating and memory in in vivo models of schizophrenia. Orally active and brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PHA 543613 hydrochloride

PHA 543613 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PHA 543613 hydrochloride

M. Wt	307.78
Formula	C₁₅H₁₇N₃O₂.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1586767-92-1
PubChem ID	56972222
InChi Key	YMTPSZUBRSEWNY-ZOWNYOTGSA-N
Smiles	O=C(C2=NC=C(OC=C3)C3=C2)N[C@@H]1C4CCN(CC4)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PHA 543613 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	30.78	100
	DMSO	7.69	25

Preparing Stock Solutions for PHA 543613 hydrochloride

The following data is based on the product molecular weight 307.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.25 mL	32.49 mL
5 mM	0.65 mL	3.25 mL	6.50 mL
10 mM	0.32 mL	1.62 mL	3.25 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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References for PHA 543613 hydrochloride

References are publications that support the biological activity of the product.

Faghih Allosteric modulators of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 2008 PMID: 18198823
Acker Discovery of N-[3R,5R)-1-azabicyclo[3.2.1]ocy-3-yl]furo-[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: in vitro and in vivo activity. Bioorg.Med.Chem.Letts. 2008 PMID: 1849016
Wishka Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia; synthesis and st J.Med.Chem. 2006 PMID: 16821801