PHA 568487

Name: PHA 568487
Brand: Tocris Bioscience
SKU: 3134

Tocris Bioscience, part of Bio-Techne | Catalog # 3134

Citations (18)

COA / SDS

Selective α7 nAChR agonist

Key Product Details

Description:	Selective α7 nAChR agonist
Chemical Name:	N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide fumarate
Purity:	≥99% (HPLC)
Molecular Weight:	404.41

View Full Technical Details for PHA 568487

Technical Data
Citations

Biological Activity for PHA 568487

PHA 568487 is an agonist of the α7 nicotinic acetylcholine receptor (K_i values are 44 and 2800 for α7 and 5-HT₃ respectively, IC₅₀ values are > 100 μM for α3β4 and α1β1δγ respectively, and % inhibition is < 1 and 5% for α4β2 and hERG respectively). Orally active and brain penetrant.

Compound Libraries for PHA 568487

PHA 568487 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PHA 568487

M. Wt	404.41
Formula	C₁₆H₂₀N₂O₃.C₄H₄O₄
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	527680-57-5
PubChem ID	56972212
InChi Key	QYQZUGYJVHHHEE-QDSMGTAFSA-N
Smiles	O=C(C3=CC=C(OCCO4)C4=C3)N[C@@H]1C2CCN(CC2)C1.O=C(/C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PHA 568487

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	40.44	100
	DMSO	40.44	100

Preparing Stock Solutions for PHA 568487

The following data is based on the product molecular weight 404.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for PHA 568487

References are publications that support the biological activity of the product.

Walker Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists. Bioorg.Med.Chem. 2006 PMID: 17011782