PI 828

Name: PI 828
Brand: Tocris Bioscience
SKU: 2814

Tocris Bioscience, part of Bio-Techne | Catalog # 2814

(1)

Citations (27)

COA / SDS

PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)

Key Product Details

Chemical Name:	2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
Purity:	≥98%

View Full Technical Details for PI 828

Technical Data
Citations / Reviews (1)

Biological Activity for PI 828

PI 828 is a PI 3-Kinase inhibitor (IC₅₀ values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.

Technical Data for PI 828

Formula	C₁₉H₁₈N₂O₃
Storage	Store at +4°C
Purity	≥98%
CAS Number	942289-87-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PI 828

Solubility

Soluble Soluble to 100 mM in DMSO

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References for PI 828

References are publications that support the biological activity of the product.

Park, Meeyoung, Ohana, Ehud, Choi, Soo Youn, Lee, Myeong-S, Park, Jong Hoo, Muallem, Shmuel Multiple roles of the SO4(2-)/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions. J Biol Chem, 2014;289(4):1993-2001. 2014 PMID: 24302720
Kulkarni A, Roy B, Rao P, Wyant G, Mahmoud A, Ramachandran M, Sengupta P, Goldman A, Kotamraju V, Basu S, Mashelkar R, Ruoslahti E, Dinulescu D, Sengupta S Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res, 2013;73(23):6987-97. 2013 PMID: 24121488
N Mahfouz, R Tahtouh, N Alaaeddine, J El Hajj, R Sarkis, R Hachem, I Raad, G Hilal Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1? and VEGF receptors PLoS ONE, 2017;12(6):e0179202. 2017 PMID: 28594907
Gharbi et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem.J., 2007;404:15 PMID: 17302559

PI 828

Tocris Bioscience, part of Bio-Techne | Catalog # 2814

Key Product Details

Biological Activity for PI 828

Technical Data for PI 828

Solubility for PI 828

Dilution Calculator

Reconstitution Calculator

References for PI 828

Product Documents for PI 828

COA

Certificate of Analysis

SDS

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