Pioglitazone hydrochloride

Name: Pioglitazone hydrochloride
Brand: Tocris Bioscience
SKU: 4124
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4124

(1)

Citations (9)

COA / SDS

Selective PPARγ agonist; antidiabetic agent

Key Product Details

Description:	Selective PPARγ agonist; antidiabetic agent
Chemical Name:	5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	392.9

View Full Technical Details for Pioglitazone hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Pioglitazone hydrochloride

Pioglitazone hydrochloride is a selective PPARγ agonist (EC₅₀ = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity. Also enhances proliferation and survival of mESCs and acts synergistically with Y-27632 (Cat. No. 1254) to improve survival of dissociated single hPSCs and increase colony formation.

Compound Libraries for Pioglitazone hydrochloride

Pioglitazone hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Pioglitazone hydrochloride

M. Wt	392.9
Formula	C₁₉H₂₀N₂O₃S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	112529-15-4
PubChem ID	60560
InChi Key	GHUUBYQTCDQWRA-UHFFFAOYSA-N
Smiles	O=C(S3)NC(C3CC(C=C2)=CC=C2OCCC1=NC=C(CC)C=C1)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pioglitazone hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.82	25

Preparing Stock Solutions for Pioglitazone hydrochloride

The following data is based on the product molecular weight 392.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.18 mL	50.90 mL	101.81 mL
1.25 mM	2.04 mL	10.18 mL	20.36 mL
2.5 mM	1.02 mL	5.09 mL	10.18 mL
12.5 mM	0.20 mL	1.02 mL	2.04 mL

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References for Pioglitazone hydrochloride

References are publications that support the biological activity of the product.

Kajabadi The synergistic enhancement of cloning efficiency in individualized human pluripotent stem cells by peroxisome proliferative-activated receptor-γ (PPARγ) activation and Rho-associated kinase (ROCK) inhibition. J.Biol.Chem. 2015 PMID: 26336103
Sakamoto Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglit. Biochem.Biophys.Res.Commun. 2000 PMID: 11095972
Momose Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as Ins sensitizers with antidiabetic activities. J.Med.Chem. 2002 PMID: 11906293
Willson The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 1996 PMID: 8576907