PLpro inhibitor 19

Name: PLpro inhibitor 19
Brand: Tocris Bioscience
SKU: 7505

Tocris Bioscience, part of Bio-Techne | Catalog # 7505

COA / SDS

SARS-CoV-2 PLpro and replication inhibitor

Key Product Details

Description:	SARS-CoV-2 PLpro and replication inhibitor
Chemical Name:	(R)-N-(3-Fluoro-5-((1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxamido)methyl)phenyl)-4-methylpiperazine-1-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	531.68

View Full Technical Details for PLpro inhibitor 19

Technical Data
Citations

Biological Activity for PLpro inhibitor 19

PLpro inhibitor 19 is a SARS-CoV-2 inhibitor that inhibits viral replication and PLpro enzymatic activity in vitro (IC₅₀ values are 0.18 μM and 0.44 μM respectively). PLpro inhibitor 19 is selective for PLpro over human deubiquitinating enzymes (DUBs) and DUB-like proteases and displays no cytotoxicity at up to 10 μM.

Technical Data for PLpro inhibitor 19

M. Wt	531.68
Formula	C₃₁H₃₈FN₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2863607-73-0
PubChem ID	155925847
InChi Key	ZGUISYSWQQIAHK-JOCHJYFZSA-N
Smiles	CN1CCN(CC1)C(NC2=CC(F)=CC(CNC(C3CCN(CC3)[C@@H](C4=C5C=CC=CC5=CC=C4)C)=O)=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PLpro inhibitor 19

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	53.17	100
	ethanol	53.17	100

Preparing Stock Solutions for PLpro inhibitor 19

The following data is based on the product molecular weight 531.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.88 mL	9.40 mL	18.81 mL
5 mM	0.38 mL	1.88 mL	3.76 mL
10 mM	0.19 mL	0.94 mL	1.88 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for PLpro inhibitor 19

References are publications that support the biological activity of the product.

Shan Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem.Biol. 2021 PMID: 33979649