PMPA (NAALADase inhibitor)

Name: PMPA (NAALADase inhibitor)
Brand: Tocris Bioscience
SKU: 1380

Tocris Bioscience, part of Bio-Techne | Catalog # 1380

Citations (3)

COA / SDS

GCP II inhibitor

Key Product Details

Description:	GCP II inhibitor
Chemical Name:	2-(Phosphonomethyl)pentane-1,5-dioic acid
Molecular Weight:	226.12

View Full Technical Details for PMPA (NAALADase inhibitor)

Technical Data
Citations

Biological Activity for PMPA (NAALADase inhibitor)

PMPA (NAALADase inhibitor) is a highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a K_i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Technical Data for PMPA (NAALADase inhibitor)

M. Wt	226.12
Formula	C₆H₁₁O₇P
Storage	Desiccate at RT
CAS Number	173039-10-6
PubChem ID	10130754
InChi Key	ISEYJGQFXSTPMQ-UHFFFAOYSA-N
Smiles	OC(=O)CCC(CP(=O)(O)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PMPA (NAALADase inhibitor)

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	22.61	100

Preparing Stock Solutions for PMPA (NAALADase inhibitor)

The following data is based on the product molecular weight 226.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.42 mL	22.11 mL	44.22 mL
5 mM	0.88 mL	4.42 mL	8.84 mL
10 mM	0.44 mL	2.21 mL	4.42 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

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References for PMPA (NAALADase inhibitor)

References are publications that support the biological activity of the product.

Rahn Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc.Natl.Acad.Sci.U S A (Epub ahead of print] 2012 PMID: 23169655
Slusher Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 1999 PMID: 10581082
Thomas NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 2003 PMID: 12826236
Jackson Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 1996 PMID: 8558536