PND 1186

Name: PND 1186
Brand: Tocris Bioscience
SKU: 6891

Tocris Bioscience, part of Bio-Techne | Catalog # 6891

Citations (4)

COA / SDS

Potent FAK inhibitor; orally bioavailable

Key Product Details

Description:	Potent FAK inhibitor; orally bioavailable
Chemical Name:	2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	501.51

View Full Technical Details for PND 1186

Technical Data
Citations

Biological Activity for PND 1186

PND 1186 is a potent FAK inhibitor (IC₅₀ values are 1.5 and 100 nM for recombinant FAK and FAK in breast carcinoma cells, respectively). Promotes caspase activation; triggering apoptosis. Inhibits 4T1 breast carcinoma subcutaneous tumor growth and breast carcinoma cell motility. Decreases spontaneous breast to lung metastasis in pre-clinical models. Orally bioavailable.

Compound Libraries for PND 1186

PND 1186 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for PND 1186

M. Wt	501.51
Formula	C₂₅H₂₆F₃N₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1061353-68-1
PubChem ID	25073775
InChi Key	IGUBBWJDMLCRIK-UHFFFAOYSA-N
Smiles	CNC(=O)C1=C(NC2=CC(NC3=C(OC)C=C(C=C3)N3CCOCC3)=NC=C2C(F)(F)F)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PND 1186

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.15	100

Preparing Stock Solutions for PND 1186

The following data is based on the product molecular weight 501.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for PND 1186

References are publications that support the biological activity of the product.

Tanjoni PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol.Ther. 2010 PMID: 20234191
Jiang Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy. Nat.Med. 2016 PMID: 27376576
Walsh Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol.Ther. 2010 PMID: 20234193