POM 1

Name: POM 1
Brand: Tocris Bioscience
SKU: 2689
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2689

(1)

Citations (76)

COA / SDS

Inhibitor of E-NTPDases

Key Product Details

Description:	Inhibitor of E-NTPDases
Alternative Names:	Sodium polyoxotungstate
Chemical Name:	Sodium metatungstate
Molecular Weight:	2986.01

View Full Technical Details for POM 1

Technical Data
Citations / Reviews (1)

Biological Activity for POM 1

POM 1 is an inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y₁₂ (K_i values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y₁₂ and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Technical Data for POM 1

M. Wt	2986.01
Formula	H₂O₄₀Na₆W₁₂
Storage	Store at RT
CAS Number	12141-67-2
PubChem ID	71311259
InChi Key	YVQUUPJGDSQKML-UHFFFAOYSA-N
Smiles	O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O.[O-][W]([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for POM 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	298.6	100

Preparing Stock Solutions for POM 1

The following data is based on the product molecular weight 2986.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.33 mL	1.67 mL	3.35 mL
5 mM	0.07 mL	0.33 mL	0.67 mL
10 mM	0.03 mL	0.17 mL	0.33 mL
50 mM	0.01 mL	0.03 mL	0.07 mL

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References for POM 1

References are publications that support the biological activity of the product.

Grenz Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 2007 PMID: 17442731
Muller Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg.Med.Chem.Lett. 2006 PMID: 16997558