Proglumide sodium salt

Name: Proglumide sodium salt
Brand: Tocris Bioscience
SKU: 1478

Tocris Bioscience, part of Bio-Techne | Catalog # 1478

Citations (32)

COA / SDS

Non-selective CCK antagonist; orally active

Key Product Details

Description:	Non-selective CCK antagonist; orally active
Chemical Name:	4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	356.39

View Full Technical Details for Proglumide sodium salt

Technical Data
Citations

Biological Activity for Proglumide sodium salt

Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.

Technical Data for Proglumide sodium salt

M. Wt	356.39
Formula	C₁₈H₂₅N₂NaO₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	99247-33-3
PubChem ID	23677833
InChi Key	UFMWGCINVOIJSO-UHFFFAOYSA-M
Smiles	[Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Proglumide sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	35.64	100

Preparing Stock Solutions for Proglumide sodium salt

The following data is based on the product molecular weight 356.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.06 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

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References for Proglumide sodium salt

References are publications that support the biological activity of the product.

Mauss Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells. Anticancer Res. 1994 PMID: 8166452
Hahne Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci.U.S.A. 1981 PMID: 6171817
Iwamoto In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol.Jpn. 1984 PMID: 6202584