PRX 07034

Name: PRX 07034
Brand: Tocris Bioscience
SKU: 6748

Tocris Bioscience, part of Bio-Techne | Catalog # 6748

COA / SDS

Potent and selective 5-HT6 antagonist

Key Product Details

Description:	Potent and selective 5-HT₆ antagonist
Chemical Name:	N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)aniline hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	490.44

View Full Technical Details for PRX 07034

Technical Data
Citations

Biological Activity for PRX 07034

PRX 07034 is a potent and selective 5-HT₆ receptor antagonist (IC₅₀ = 19 nM, K_i = 4 - 8 nM). Enhances working memory in rats.

Compound Libraries for PRX 07034

PRX 07034 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PRX 07034

M. Wt	490.44
Formula	C₂₁H₂₈ClN₃O₄S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	903580-39-2
PubChem ID	23653584
InChi Key	PILCQJJJAFRKHO-UHFFFAOYSA-N
Smiles	ClC1=CC(C(NC2=C(S(C)(=O)=O)C=CC(N3CCNCC3)=C2)C)=C(OC)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PRX 07034

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	9.81	20 with gentle warming
	DMSO	49.04	100

Preparing Stock Solutions for PRX 07034

The following data is based on the product molecular weight 490.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.19 mL	20.39 mL
5 mM	0.41 mL	2.04 mL	4.08 mL
10 mM	0.20 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for PRX 07034

References are publications that support the biological activity of the product.

Mohler The effects of PRX-07034, a novel 5-HT₆ antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 PMID: 21989804