PSB 1115

Name: PSB 1115
Brand: Tocris Bioscience
SKU: 2009

Tocris Bioscience, part of Bio-Techne | Catalog # 2009

Citations (497)

COA / SDS

Selective human A2B antagonist; water-soluble

Key Product Details

Chemical Name:	4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid
Purity:	≥98%
Molecular Weight:	350.35 kDa

View Full Technical Details for PSB 1115

Technical Data
Citations

Biological Activity for PSB 1115

PSB 1115 is a highly selective, water-soluble, human A_2B adenosine receptor antagonist. K_i values are 53.4, > 10000 and > 10000 nM at human A_2B, A₁ and A₃ receptors respectively. Also selective versus rat A₁ and A_2A receptors (K_i values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo.

Technical Data for PSB 1115

M. Wt	350.35 kDa
Formula	C₁₄H₁₄N₄O₅S
Storage	Store at RT
Purity	≥98%
CAS Number	152529-79-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSB 1115

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming

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References for PSB 1115

References are publications that support the biological activity of the product.

Y Zhang, P Chen, G Di, X Qi, Q Zhou, H Gao Netrin-1 promotes diabetic corneal wound healing through molecular mechanisms mediated via the adenosine 2B receptor Sci Rep, 2018;8(1):5994. 2018 PMID: 29662125
Warren, Cirle A, Li, Yuesheng, Calabrese, Gina M, Freire, Rosemayr, Zaja-Milatovic, Snjezana, van Opstal, Edward, Figler, Robert A, Linden, Joel, Guerrant, Richard Contribution of adenosine A(2B) receptors in Clostridium difficile intoxication and infection. Infect Immun, 2012;80(12):4463-73. 2012 PMID: 23045479
Abo-Salem et al. Antinociceptive effects of novel A_2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther., 2004;308:358 PMID: 14563788
Muller et al. 8-(Sulfostyryl)xanthines: water-soluble A_2A-selective adenosine receptor antagonists. Bioorg.Med.Chem., 1998;6:707 PMID: 9681137
Hayallah et al. 1,8-Disubstituted xanthine derivatives: synthesis of potent A_2B-selective adenosine receptor antagonists. J.Med.Chem., 2002;45:1500 PMID: 11906291
Yan and Muller Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. J.Med.Chem., 2004;47:1031 PMID: 14761205