PSEM 308 hydrochloride

Name: PSEM 308 hydrochloride
Brand: Tocris Bioscience
SKU: 6425

Tocris Bioscience, part of Bio-Techne | Catalog # 6425

Citations (1)

COA / SDS

PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

Key Product Details

Description:	PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ chimeric ion channel agonist
Chemical Name:	5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3',2':3,4]diazepino[6,7,1-hi]indole hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	303.83

View Full Technical Details for PSEM 308 hydrochloride

Technical Data
Citations

Biological Activity for PSEM 308 hydrochloride

PSEM 308 hydrochloride is a PSAM (pharmacologically selective actuator module) agonist. Activates PSAM^L141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAM^L141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAM^L141F,Y115F-5-HT₃ ion channels.

Recommended concentration for use in mice is 5 mg/kg or lower.

Plasmid vectors for the transfection of cells with PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ are available from Addgene.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Technical Data for PSEM 308 hydrochloride

M. Wt	303.83
Formula	C₁₇H₂₁N₃.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	134812838
InChi Key	VMTPPUMVLGEJNP-UHFFFAOYSA-N
Smiles	CC1CC2=CC=CC3=C2N1N=C4C(C3)[N@@]5CC[C@H]4CC5.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSEM 308 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	6.08	20
	ethanol	6.08	20 with gentle warming

Preparing Stock Solutions for PSEM 308 hydrochloride

The following data is based on the product molecular weight 303.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	16.46 mL	82.28 mL	164.57 mL
1 mM	3.29 mL	16.46 mL	32.91 mL
2 mM	1.65 mL	8.23 mL	16.46 mL
10 mM	0.33 mL	1.65 mL	3.29 mL

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References for PSEM 308 hydrochloride

References are publications that support the biological activity of the product.

Hirschberg Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 2017 PMID: 29027903
Satoh Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons. Neuron 2016 PMID: 26924434
Atasoy Deconstruction of a neural circuit for hunger. Nature 2012 PMID: 22801496
Lovett-Barron Regulation of neuronal input transformations by tunable dendritic inhibition. Nat.Neurosci. 2012 PMID: 22246433